Between 20 and 30% of prostate cancer patients relapse and ultimately suffer from metastases. For more than 60 years now, hormone therapy has been found to be the most effective approach to treat this disease. However, after a prolonged period of treatment, such patients become resistant to hormone therapy. Up until 2004, this particular group of patients, termed as having castration-resistant prostate cancer, had a 12-month survival rate, but nowadays, thanks to the development of novel, more effective therapeutics, have a survival rate of 3 - 4 years. The Oncology Department of the Vall d'Hebron University Hospital diagnoses 100 new cases of prostate cancer each year, 70 of which are castration-resistant.
The main lines of research that are currently being developed in this field at the Vall d'Hebron Institute of Oncology (VHIO) and at other centres of international reference, seek to develop new drugs to overcome treatment resistance in this group of patients, and thus improve both quality of life and life expectancy.
On 24 May, VHIO and the Vall d'Hebron University Hospital will host a half-day workshop, New Paradigm in Castration-Resistant Prostate Cancer: Meet the Experts, welcoming a panel of internationally renowned speakers including Dr. Charles Ryan, University of California (San Francisco), Dr. Karim Fizazi, the Institute Gustave-Roussy (IGR, Paris), and Dr. David Olmos, the Spanish National Cancer Research Centre (CNIO, Madrid). The aim of the meeting is to update on the very latest advances in prostate cancer and provide the platform for debate and exchange with eminent leaders within the field. Specifically, Dr. David Olmos will present on new analysis tools for translational research in prostate cancer patients, Dr. Karim Fizazi will share the results of a study on the role of CYP-17 inhibitors in the treatment of CRPC, since this enzyme plays a key role in tumour resistance to hormone therapy, and Dr. Charles Ryan will discuss abiraterone and new hormonal treatments in CRPC. Furthermore, Dr. Josep Tabernero, Head of the Medical Oncology Department, the Vall d'Hebron University Hospital, and Director of VHIO, will present on clinical and translational research at VHIO, as well as the Institute´s future directions.
This meeting, led by Dr. Joan Carles, Head of the Vall d´Hebron University Hospital´s Genitourinary Unit, and Principal Investigator of VHIO´s Genitourinary, CNS Tumors, Sarcoma & Cancer of Unknown Primary Site Group, will draw the participation of urologists, radiation oncologists and oncologists throughout Spain. The workshop will also incorporate two Case Discussion sessions led by the speakers, who will share their respective experiences and viewpoints. These sessions will be moderated by Dr. Rafael Morales and Dr. Cristina Suárez. Following conclusions and take-home messages, the workshop will be closed by Dr. Joan Carles.
VHIO: at the forefront of prostate cancer research
Through the organization of such high-level scientific meetings, on this occasion focused on prostate cancer, the Vall d'Hebron Institute of Oncology (VHIO) promotes and develops collaboration with other research centers and entities of excellence in oncology such as the University of California and the Institute Gustave-Roussy (IGR), placing VHIO at the very forefront of international research. These centres are currently working together to develop new therapeutics for castration-resistant prostate cancer patients (hormone treatment resistance).
VHIO´s Genitourinary, CNS Tumors, Sarcoma & Cancer of Unknown Primary Site Group,headed by Dr. Joan Carles, has grown significantly over the last four years in terms of the number of on-going clinical trials and study subjects enrolled, with 19 trials launched in 2012 and another 23 expected to start this year. The group publishes an increasing number of papers and its impact factor has risen from 17.68 in 2009 to 130.06 in 2012.